Incidence of clinical outcomes in heart failure patients with and without advanced chronic kidney disease.

ABSTRACT:

Aims

Chronic kidney disease (CKD) is a well-established risk factor for heart failure (HF); however, patients with an estimated glomerular filtration rate (eGFR) < 30 mL/min/1.73 m² have been systematically excluded from clinical trials. This study investigated the incidence of HF and kidney outcomes in HF patients with and without advanced CKD, that is, eGFR < 30.

Methods

From nationwide registries, HF patients were identified from 2014 to 2018 and categorized into three groups according to baseline eGFR (eGFR ≥ 60, 60 > eGFR ≥ 30 and eGFR < 30). The incidence of primary outcomes (all-cause mortality, HF hospitalization, end-stage kidney disease and sustained 50% eGFR decline) was estimated using cumulative incidence functions.

Results

Of the 21 959 HF pat

SUBMITTER: Zahir Anjum D 

PROVIDER: S-EPMC11424275 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature