Type 2 diabetes mellitus and cardiovascular health: Evidence of causal relationships in a European ancestry population.

ABSTRACT:

Aims

Type 2 diabetes mellitus (T2DM) is associated with increased cardiovascular disease (CVD) risk, but whether T2DM directly causes adverse cardiac remodelling is uncertain. We performed a comprehensive Mendelian randomization (MR) analysis to investigate the causal relevance of T2DM to CVD outcomes and cardiac structure/function.

Methods and results

Bidirectional two-sample MR was conducted using summary-level data from European-ancestry genome-wide association studies. The T2DM GWAS data included 80 154 cases and 853 816 controls from the DIAGRAM consortium. Outcomes included coronary artery disease (CAD), myocardial infarction (MI), stroke, heart failure, atrial fibrillation, and various quantitative cardiac imaging traits assessed by magnetic resonance imaging. MR anal

SUBMITTER: Ruan W 

PROVIDER: S-EPMC11424321 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature