Phenotype and outcomes according to loop diuretic use in pulmonary arterial hypertension.

ABSTRACT:

Aims

The use of loop diuretics in pulmonary arterial hypertension (PAH) is less frequent compared with heart failure. The clinical and prognostic characteristics of PAH patients according to loop diuretic use remain unexplored. In this study, we retrospectively analysed the characteristics and survival of PAH patients requiring different doses of loop diuretics.

Methods and results

Patients diagnosed with PAH between 2001 and 2022 at seven European centres for the management of PAH. According to the median equivalent dose of furosemide in the overall cohort, patients were divided into two subgroups: no/low-dose loop diuretic and high-dose loop diuretic. Primary outcome was 5 year all-cause mortality. Among the 397 patients included, 227 (57%) were treated with loop diuretics

SUBMITTER: Savonitto G 

PROVIDER: S-EPMC11424338 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature