Long-term outcomes of phenoclusters in preclinical heart failure with preserved and mildly reduced ejection fraction.

ABSTRACT:

Aims

The identification of subjects at higher risk for incident heart failure (HF) with preserved ejection fraction (EF) suitable for more intensive preventive programmes remains challenging. We applied phenomapping to the DAVID-Berg population, comprising subjects with preclinical HF, aiming to refine HF risk stratification.

Methods

The DAVID-Berg study prospectively enrolled 596 asymptomatic outpatients with EF > 40% with hypertension, diabetes mellitus or known cardiovascular disease. In this cohort, we performed an unsupervised cluster analysis on 591 patients, including clinical, laboratory, electrocardiographic and echocardiographic parameters. We tested the association between each cluster and a composite outcome of HF/death.

Results

The median age was 70 years

SUBMITTER: Fazzini L 

PROVIDER: S-EPMC11424346 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature