Circulating brain-derived neurotrophic factor levels and heart failure: A systematic review and meta-analysis.

ABSTRACT:

Aims

Biomarkers are paramount for managing heart failure (HF) patients as prognostic and therapeutic efficacy index tools. Systemic levels of brain-derived neurotrophic factor (BDNF) can add to the HF biomarker scenario, allowing for potentiated efficacy in diagnosis, prognostic stratification, and prediction of patient response to a given therapeutic intervention because BDNF is one of the primary rulers of myocardial function. Yet, whether BDNF is a reliable clinical biomarker awaits clinical validation. Hence, we aimed to answer this relevant question via a systematic review and meta-analysis of existing studies.

Methods and results

International databases, including PubMed, Scopus, Embase, and the Web of Science, were comprehensively searched for studies assessing BDNF l

SUBMITTER: Behnoush AH 

PROVIDER: S-EPMC11424347 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature