Predicting cardiovascular events with fluoropyrimidine chemotherapy using a standard cardiovascular risk calculator.

ABSTRACT:

Aims

Fluoropyrimidine chemotherapy is important for treatment of many solid tumours but is associated with cardiotoxicity. The relationship of fluoropyrimidine-associated cardiotoxicity (FAC) with conventional cardiovascular (CV) risk factors is poorly understood, and standard cardiovascular risk scores are not validated in this context.

Methods and results

Single-centre retrospective study of patients treated with fluoropyrimidine chemotherapy using electronic health records for cardiovascular risk factors (and calculation of QRISK3 score), cancer treatment, and clinical outcomes. FAC was defined by cardiovascular events during or within 3 months of fluoropyrimidine treatment, and Cox regression was used to assess associations of CV risk and cancer treatment with FAC. One t

SUBMITTER: Abiodun A 

PROVIDER: S-EPMC11424348 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature