Clusters of multidimensional exercise response patterns and estimated heart failure risk in the Framingham Heart Study.

ABSTRACT:

Aims

New tools are needed to identify heart failure (HF) risk earlier in its course. We evaluated the association of multidimensional cardiopulmonary exercise testing (CPET) phenotypes with subclinical risk markers and predicted long-term HF risk in a large community-based cohort.

Methods and results

We studied 2532 Framingham Heart Study participants [age 53 ± 9 years, 52% women, body mass index (BMI) 28.0 ± 5.3 kg/m², peak oxygen uptake (VO₂) 21.1 ± 5.9 kg/m² in women, 26.4 ± 6.7 kg/m² in men] who underwent maximum effort CPET and were not taking atrioventricular nodal blocking agents. Higher peak VO₂ was associated with a lower estimated HF risk score (Spearman correlation r: -0.60 in men and -0.55 in women, P < 0.000

SUBMITTER: Miller PE 

PROVIDER: S-EPMC11424363 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature