Overexpression of zinc-finger protein 418 inhibits pathological cardiac remodelling after acute myocardial infarction.

ABSTRACT:

Aims

Zinc-finger protein 418 (ZNF418) has been confirmed to be expressed in myocardial tissue. However, the role and mechanism of ZNF418 in pathological myocardial remodelling after myocardial infarction (MI) have not been reported. This study was to elucidate the effect and mechanism of ZNF418 on ventricular remodelling after MI in mice.

Methods and results

MI mice and H9c2 cardiomyocytes were used to conduct in vivo and in vitro experiments, respectively. ZNF418 expression was regulated by adeno-associated virus 9 and adenovirus vectors. Pathological analysis, echocardiography, and molecular analysis were performed. ZNF418 was down-regulated in the left ventricular tissues of post-MI mice. In contrast, ZNF418 overexpression decreased mortality and improved cardiac function

SUBMITTER: Jiang H 

PROVIDER: S-EPMC11424367 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature