Transplantation of autologous mesenchymal stromal cells in complete cervical spinal cord injury: a pilot study.

ABSTRACT:

Objective

Spinal cord injury (SCI) is a serious condition that can lead to partial or complete paraplegia or tetraplegia. Currently, there are few therapeutic options for these conditions, which are mainly directed toward the acute phase, such as surgical intervention and high-dose steroid administration. Mesenchymal stromal cells (MSC) have been shown to improve neurological function following spinal cord injury. The aim of the study was to evaluate the safety, feasibility, and potential efficacy of MSC transplantation in patients with cervical traumatic SCI.

Methods

We included seven subjects with chronic traumatic SCI (> 1 year) at the cervical level, classified as American Spinal Cord Injury Association impairment scale (AIS) grade A. Subjects received two doses of autol

SUBMITTER: Macedo CT 

PROVIDER: S-EPMC11424397 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature