Identification of cellular senescence-related genes and immune cell infiltration characteristics in intervertebral disc degeneration.

ABSTRACT:

Background

Intervertebral disc degeneration (IDD) progression involves multiple factors, including loss of nucleus pulposus cells and extracellular matrix as the basic pathological mechanism of degeneration, and is closely related to cellular senescence and immune cell infiltration. The aim of study was to identify critical cellular senescence-related genes and immune cell infiltration characteristics in IDD.

Methods

Four datasets, including GSE70362, GSE112216, GSE114169, and GSE150408, were downloaded from the Gene Expression Omnibus database. The senescence-related genes were acquired from the CellAge Database and intersected with differentially expressed genes (DEGs) between IDD and control samples for senescence-related DEGs (SRDEGs). Protein-protein interaction (PPI) n

SUBMITTER: Wang M 

PROVIDER: S-EPMC11424418 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature