Self-organized tissue mechanics underlie embryonic regulation.

ABSTRACT: Early amniote development is highly self-organized, capable of adapting to interference through local and long-range cell-cell interactions. This process, called embryonic regulation¹, has been well illustrated in experiments on avian embryos, in which subdividing the epiblast disk into different parts not only redirects cell fates to eventually form a complete and well-proportioned embryo at its original location, but also leads to the self-organization of additional, fully formed embryos^2,3 in the other separated parts. The cellular interactions underlying embryonic self-organization are widely believed to be mediated by molecular signals, yet the identity of such signals is unclear. Here, by analysing intact and mechanically perturbed quail embryos, we show that th

SUBMITTER: Caldarelli P 

PROVIDER: S-EPMC11424473 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature