Fibrin drives thromboinflammation and neuropathology in COVID-19.

ABSTRACT: Life-threatening thrombotic events and neurological symptoms are prevalent in COVID-19 and are persistent in patients with long COVID experiencing post-acute sequelae of SARS-CoV-2 infection^1-4. Despite the clinical evidence^1,5-7, the underlying mechanisms of coagulopathy in COVID-19 and its consequences in inflammation and neuropathology remain poorly understood and treatment options are insufficient. Fibrinogen, the central structural component of blood clots, is abundantly deposited in the lungs and brains of patients with COVID-19, correlates with disease severity and is a predictive biomarker for post-COVID-19 cognitive deficits^1,5,8-10. Here we show that fibrin binds to the SARS-CoV-2 spike protein, forming proinflammatory blood clots that drive syste

SUBMITTER: Ryu JK 

PROVIDER: S-EPMC11424477 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature