Safety assessment of sulfasalazine: a pharmacovigilance study based on FAERS database.

ABSTRACT:

Background

Sulfasalazine is a widely used anti-inflammatory medication for treating autoimmune disorders such as ulcerative colitis (UC), Crohn's disease, and rheumatoid arthritis. However, its safety profile has not been systematically evaluated in real-world settings. By analyzing the FDA Adverse Event Reporting System (FAERS) database, we identified risk signals associated with adverse reactions to sulfasalazine, offering valuable insights for clinical decision-making and risk management.

Methods

Reports of adverse events (AEs) associated with sulfasalazine, covering the period from Q1 2004 to Q4 2023, were extracted from the FAERS database. Detailed case information was aggregated to assess demographic characteristics. The associations between sulfasalazine and adverse e

SUBMITTER: Ye W 

PROVIDER: S-EPMC11424536 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature