Decisive gene strategy on osteoarthritis: a comprehensive whole-literature based approach for conclusive gene targets.

ABSTRACT:

Background

Previous meta-analyses only examined the association between single or several gene polymorphisms and osteoarthritis (OA), whereas no studies have concluded that there are existing all gene loci that associate with OA.

Objective

To assess whether a definite conclusion of the association between the gene loci and OA can be drawn.

Methods

Decisive gene strategy (DGS), a literature-based approach, was used to search PubMed, Embase, and Cochrane databases for all meta-analyses that associated gene polymorphisms and OA. Trial Sequential Analysis (TSA) examined the sufficiency of the cumulative sample size. Finally, we assessed the importance of gene loci in OA based on whether there were enough sample sizes and the heterogeneity of the literatures with I^2</

SUBMITTER: Chen YC 

PROVIDER: S-EPMC11424587 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature