Unveiling the anticancer potential of <i>Anamirta cocculus</i> (L.) Wight& Arn.: Evidences from cytotoxicity studies, apoptosis analysis, and molecular docking.

ABSTRACT: Anamirta cocculus, a woody climber, is extensively utilised in traditional Asian medicine. This study investigates the cytotoxic effects of A. cocculus leaf extracts on various cancer cell lines as well as on a normal cell line. The ethyl acetate extract exhibited potent anticancer activity, with the highest cytotoxicity observed against ovarian cancer cell line (PA1) (IC₅₀ = 8.30 ± 0.38 µg/mL) and colorectal adenocarcinoma cell line (HT29) (IC₅₀ = 17.97 ± 0.63 µg/mL). Notably, the extract displayed low toxicity (18.72 ± 0.73%) on the normal human keratinocyte cell line (HaCaT) at a concentration of 100 µg/mL, indicating selective cytotoxicity towards cancer cells. The acetone extract also demonstrated significant cytotoxicity against various cancer cell

SUBMITTER: Thozhukkad Moosaripparambil S 

PROVIDER: S-EPMC11424601 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature