Diabetes compromises tight junction protein claudin 14 in the urinary bladder.

ABSTRACT: Infections are common in patients with diabetes. Moreover, increasing incidence of antibiotic resistance impedes the complete bacterial clearance and calls for alternative treatment strategies. Along with antibacterial resistance, compromised host conditions create a favorable condition for the disease progression. In particular, cell junction proteins are of major importance as they contribute to a tight cell barrier, protecting against invading pathogens. However, the impact of high glucose on cell junction proteins has received little attention in the urinary bladder but merits closer investigation. Here, we report that during diabetes the expression of cell junction protein, claudin 14 is compromised in the human urine exfoliated cells and in the urinary bladder of type 2 diabetic mous

SUBMITTER: Mohanty S 

PROVIDER: S-EPMC11424655 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature