Multilocus patterns of nucleotide variability and the demographic and selection history of Drosophila melanogaster populations.

ABSTRACT: Uncertainty about the demographic history of populations can hamper genome-wide scans for selection based on population genetic models. To obtain a portrait of the effects of demographic history on genome variability patterns in Drosophila melanogaster populations, we surveyed noncoding DNA polymorphism at 10 X-linked loci in large samples from three African and two non-African populations. All five populations show significant departures from expectations under the standard neutral model. We detect weak but significant differentiation between East (Kenya and Zimbabwe) and West/Central sub-Saharan (Gabon) African populations. A skew toward high-frequency-derived polymorphisms, elevated levels of linkage disequilibrium (LD) and significant heterogeneity in levels of polymorphism and diverge

SUBMITTER: Haddrill PR 

PROVIDER: S-EPMC1142469 | biostudies-literature | 2005 Jun

REPOSITORIES: biostudies-literature