Cranial bone thickness and density anomalies quantified from CT images can identify chronic increased intracranial pressure.

ABSTRACT:

Purpose

The diagnosis of chronic increased intracranial pressure (IIP)is often based on subjective evaluation or clinical metrics with low predictive value. We aimed to quantify cranial bone changes associated with pediatric IIP using CT images and to identify patients at risk.

Methods

We retrospectively quantified local cranial bone thickness and mineral density from the CT images of children with chronic IIP and compared their statistical differences to normative children without IIP adjusting for age, sex and image resolution. Subsequently, we developed a classifier to identify IIP based on these measurements. Finally, we demonstrated our methods to explore signs of IIP in patients with non-syndromic sagittal craniosynostosis (NSSC).

Results

We quantified a signifi

SUBMITTER: Liu J 

PROVIDER: S-EPMC11424726 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature