MiRNAs as biomarkers of autism spectrum disorder: a systematic review and meta-analysis.

ABSTRACT: Autism spectrum disorder (ASD) is a neurodevelopmental disorder with complex clinical manifestations that arise between 18 and 36 months of age. Social interaction deficiencies, a restricted range of interests, and repetitive stereotyped behaviors are characteristics which are sometimes difficult to detect early. Several studies show that microRNAs (miRs/miRNAs) are strongly implicated in the development of the disorder and affect the expression of genes related to different neurological pathways involved in ASD. The present systematic review and meta-analysis addresses the current status of miRNA studies in different body fluids and the most frequently dysregulated miRNAs in patients with ASD. We used a combined approach to summarize miRNA fold changes in different studies using the mean

SUBMITTER: Garrido-Torres N 

PROVIDER: S-EPMC11424746 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature