Hypoxic-ischemic brain injury in pig after cardiac arrest - A new histopathological scoring system for non-specialists.

ABSTRACT:

Introduction

After cardiac arrest and successful resuscitation patients often present with hypoxic-ischemic brain injury, which is a major cause of death due to poor neurological outcome. The development of a robust histopathological scoring system for the reliable and easy identification and quantification of hypoxic-ischemic brain injury could lead to a standardization in the evaluation of brain damage. We wanted to establish an easy-to-use neuropathological scoring system to identify and quantify hypoxic-ischemic brain injury.

Methods

The criteria for regular neurons, hypoxic-ischemic brain injury neurons and neurons with ischemic neuronal change (ischemic change neurons) were established in collaboration with specialized neuropathologists. Nine non-specialist examiners p

SUBMITTER: Renz M 

PROVIDER: S-EPMC11424782 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature