Role of circulating T follicular helper subsets following Ty21a immunization and oral challenge with wild type <i>S</i>. Typhi in humans.

ABSTRACT: Despite decades of intense research, our understanding of the correlates of protection against Salmonella Typhi (S. Typhi) infection and disease remains incomplete. T follicular helper cells (T_FH), an important link between cellular and humoral immunity, play an important role in the development and production of high affinity antibodies. While traditional T_FH cells reside in germinal centers, circulating T_FH (cT_FH) (a memory subset of T_FH) are present in blood. We used specimens from a typhoid controlled human infection model whereby participants were immunized with Ty21a live attenuated S. Typhi vaccine and then challenged with virulent S. Typhi. Some participants developed typhoid disease (TD) and some di

SUBMITTER: Booth JS 

PROVIDER: S-EPMC11424897 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature