Cannabis-Containing Cream for CKD-Associated Pruritus: A Double-Blind, Placebo Controlled Trial.

ABSTRACT:

Rationale & objective

This study aims to compare the efficacy of a cannabis cream and a placebo in the treatment of chronic kidney disease (CKD)-associated pruritus.

Study design

A double-blind randomized controlled study.

Setting & participants

Sixty hemodialysis patients with the worst itching intensity numerical rating scale (WI-NRS) ≥3.

Exposure

Patients received cannabis cream or placebo.

Outcomes

The primary endpoint was the WI-NRS score at week 4. The secondary endpoints included the WI-NRS at week 2, the Skindex-10 score at weeks 2 and 4, and the mean difference score between baseline and week 4 for the WI-NRS and the Skindex-10 score.

Analytical approach

We used unpaired t tests or Mann Whitney U tests, along with χ² or Fisher

SUBMITTER: Anumas S 

PROVIDER: S-EPMC11424939 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature