Parsimonious immune-response endotypes and global outcome in patients with traumatic brain injury.

ABSTRACT:

Background

The inflammatory response in patients with traumatic brain injury (TBI) offers opportunities for stratification and intervention. Previous unselected approaches to immunomodulation in patients with TBI have not improved patient outcomes.

Methods

Serum and plasma samples from two prospective, multi-centre observational studies of patients with TBI were used to discover (Collaborative European NeuroTrauma Effectiveness Research [CENTER-TBI], Europe) and validate (Transforming Research and Clinical Knowledge in Traumatic Brain Injury [TRACK-TBI] Pilot, USA) individual variations in the immune response using a multiplex panel of 30 inflammatory mediators. Mediators that were associated with unfavourable outcomes (Glasgow outcome score-extended [GOS-E] ≤ 4) were used f

SUBMITTER: Samanta RJ 

PROVIDER: S-EPMC11424973 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature