Immune-modulative nano-gel-nano system for patient-favorable cancer therapy.

ABSTRACT: Current cancer immunotherapies exhibit low response rates attributed to suppressive tumor immune microenvironments (TIMEs). To address these unfavorable TIMEs, supplementation with tumor-associated antigens and stimulation of immune cells at target sites are indispensable for eliciting anti-tumoral immune responses. Previous research has explored the induction of immunotherapy through multiple injections and implants; however, these approaches lack consideration for patient convenience and the implementation of finely tunable immune response control systems to mitigate the side effects of over-inflammatory responses, such as cytokine storms. In this context, we describe a patient-centric nano-gel-nano system capable of sustained generation of tumor-associated antigens and release of adjuva

SUBMITTER: Kim SH 

PROVIDER: S-EPMC11424977 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature