Photothermal responsive porous hollow microneedles as Chinese medicine versatile delivery system for wound healing.

ABSTRACT: Chinese medicine is identified as a candidate for wound healing. Attempts in this field tend to develop efficient dosage forms for delivering Chinese medicine with low side effects. In this paper, we proposed novel photothermal responsive porous hollow microneedles (PRPH-MNs) as a versatile Chinese medicine delivery system for efficient antibacterial wound treatment. The PRPH-MNs are composed of porous resin shells with good mechanical property, hydrogel cores, and a photothermal graphene oxide hybrid substrate. The hollow structure provides sufficient space for loading the drug dispersed hydrogel, while the porous resin shells could not only block the direct contact between drugs and wound sites but also provide channels for facilitating the drug release from the core. In addition, benefi

SUBMITTER: Zhang W 

PROVIDER: S-EPMC11425051 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature