The roles of genetic mutation and cytokines/chemokines in immune response and their association with uveal melanoma patient outcome.

ABSTRACT: The impact of tumor mutations and the interplay of cytokines and chemokines on the immune response and clinical outcomes in uveal melanoma (UM) warrants further exploration. In our study, we delved into the correlation between genetic alterations and survival rates in a cohort of 188 UM patients, utilizing data from cBioPortal. We assessed the composition of immune cell populations within 80 UM tumors by examining RNA sequence-based gene expression data from The Cancer Genome Atlas (TCGA). Furthermore, we scrutinized the relationship between genetic mutations and the expression of cytokines and chemokines, as well as their influence on various immune cell subsets. Our investigation revealed a significant association between the presence of mutated GNAQ or SF3B1 genes and improved progressi

SUBMITTER: Yong Liu 

PROVIDER: S-EPMC11425128 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature