Overcoming Cancer Persister Cells by Stabilizing the ATF4 Promoter G-quadruplex.

ABSTRACT: Persister cells (PS) selected for anticancer therapy have been recognized as a significant contributor to the development of treatment-resistant malignancies. It is found that imposing glutamine restriction induces the generation of PS, which paradoxically bestows heightened resistance to glutamine restriction treatment by activating the integrated stress response and initiating the general control nonderepressible 2-activating transcription factor 4-alanine, serine, cysteine-preferring transporter 2 (GCN2-ATF4-ASCT2) axis. Central to this phenomenon is the stress-induced ATF4 translational reprogramming. Unfortunately, directly targeting ATF4 protein has proven to be a formidable challenge because of its flat surface. Nonetheless, a G-quadruplex structure located within the promoter regio

SUBMITTER: Xiao C 

PROVIDER: S-EPMC11425212 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature