Dihydroartemisinin Modulates Enteric Glial Cell Heterogeneity to Alleviate Colitis.

ABSTRACT: The precise mechanism underlying the therapeutic effects of dihydroartemisinin (DHA) in alleviating colitis remains incompletely understood. A strong correlation existed between the elevation of glial fibrillary acidic protein (GFAP)⁺/S100 calcium binding protein B (S100β)⁺ enteric glial cells (EGCs) in inflamed colonic tissues and the disruption of the intestinal epithelial barrier (IEB) and gut vascular barrier (GVB) observed in chronic colitis. DHA demonstrated efficacy in restoring the functionality of the dual gut barrier while concurrently attenuating intestinal inflammation. Mechanistically, DHA inhibited the transformation of GFAP⁺ EGCs into GFAP⁺/S100β⁺ EGCs while promoting the differentiation of GFAP⁺/S100β^+</

SUBMITTER: Qiu P 

PROVIDER: S-EPMC11425232 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature