Copper-loaded Milk-Protein Derived Microgel Preserves Cardiac Metabolic Homeostasis After Myocardial Infarction.

ABSTRACT: Myocardial Infarction (MI) is a leading cause of death worldwide. Metabolic modulation is a promising therapeutic approach to prevent adverse remodeling after MI. However, whether material-derived cues can treat MI through metabolic regulation is mainly unexplored. Herein, a Cu²⁺ loaded casein microgel (CuCMG) aiming to rescue the pathological intramyocardial metabolism for MI amelioration is developed. Cu²⁺ is an important ion factor involved in metabolic pathways, and intracardiac copper drain is observed after MI. It is thus speculated that intramyocardial supplementation of Cu²⁺ can rescue myocardial metabolism. Casein, a milk-derived protein, is screened out as Cu²⁺ carrier through molecular-docking based on Cu²⁺ loading capacity

SUBMITTER: Hong X 

PROVIDER: S-EPMC11425262 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature