Genome-wide analysis reveals the MORC3-mediated repression of PD-L1 expression in head and neck cancer.

ABSTRACT:

Introduction

Programmed death-ligand 1 (PD-L1) plays essential roles in the negative regulation of anti-tumor immunity. However, the regulatory mechanisms of PD-L1 expression need further exploration. MORC family CW-type zinc finger 3 (MORC3) is a transcriptional factor that regulates innate immune responses, but the expression and roles of MORC3 in cancers remain largely unknown. The present study explored the expression of MORC3 in cancers at both transcriptional and translational levels.

Methods

The target genes and pathways were analyzed using RNA interference (RNAi), RNA sequencing (RNA-seq), and quantitative real-time polymerase chain reaction (qRT-PCR) technology in head and neck cancer cells. The expression of MORC3 and its target genes were also analyzed in single c

SUBMITTER: Fu W 

PROVIDER: S-EPMC11425343 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature