Interindividual variation in ovarian reserve after gonadotoxic treatment in female childhood cancer survivors - a genome-wide association study: results from PanCareLIFE.

ABSTRACT:

Objective

To discover new variants associated with low ovarian reserve after gonadotoxic treatment among adult female childhood cancer survivors using a genome-wide association study approach.

Design

Genome-wide association study.

Setting

Not applicable.

Patients

A discovery cohort of adult female childhood cancer survivors from the pan-European PanCareLIFE cohort (n = 743; median age: 25.8 years), excluding those who received bilateral ovarian irradiation, bilateral oophorectomy, central nervous system or total body irradiation, or stem cell transplantation. Replication was attempted in the US-based St. Jude Lifetime Cohort (n = 391; median age: 31.3 years).

Exposure

Female childhood cancer survivors are at risk of therapy-related gonadal impairment. Al

SUBMITTER: van der Perk MEM 

PROVIDER: S-EPMC11425505 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature