[¹⁸⁶Re]Re- and [^99mTc]Tc-Tricarbonyl Metal Complexes with 1,4,7-Triazacyclononane-Based Chelators Bearing Amide, Alcohol, or Ketone Pendent Groups.

ABSTRACT: 1,4,7-Triazacyclononane (TACN)-based chelators, such as NOTA and NODAGA, have shown great promise as bifunctional chelators for [M(CO)₃]⁺ cores (M = ^99mTc and ¹⁸⁶Re) in radiopharmaceutical development. Previous investigations of TACN-based chelators bearing pendent acid and ester arms demonstrated the important role the pendent arms have in successful coordination of the [M(CO)₃]⁺ core with the TACN backbone nitrogens. In this work, we introduce three TACN-based bifunctional chelators bearing amide, alcohol, and ketone pendent arms and evaluate their (radio)labeling efficiency with the [M(CO)₃]⁺ core as well as the in vitro stability and hydrophilicity of the resulting radiometal complexes. Follo

SUBMITTER: Hoerres R 

PROVIDER: S-EPMC11425660 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature