Increased incidence of seronegative autoimmune hepatitis in children during SARS-CoV-2 pandemia period.

ABSTRACT:

Background

Seronegative autoimmune hepatitis in children is a rare but potentially severe disease, sometimes requiring liver transplantation. This type of hepatitis may be associated with various immunological and hematological disorders, ranging from isolated lymphopenia to aplastic anemia. Precise pathophysiological mechanisms are still unknown, but the role of viruses cannot be excluded, either as directly pathogenic or as triggers, responsible for an inappropriate immune stimulation. Having the impression of an increasing number of seronegative autoimmune hepatitis since the beginning of SARS-CoV-2 pandemia period, we hypothesized that SARS-CoV-2 virus could be an infectious trigger.

Methods

We conducted a retrospective, observational, descriptive study about children wi

SUBMITTER: Schmutz M 

PROVIDER: S-EPMC11425678 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature