Analytical and Diagnostic Performance of a Dual-Target Blood Detection Test for Hepatocellular Carcinoma.

ABSTRACT:

Background

Surveillance approaches with high sensitivity and specificity for hepatocellular carcinoma (HCC) are still urgently needed. Previous studies have shown that methylation of GNB4 and Riplet can effectively diagnose HCC.

Aims

This study plan to analyze the performance of a blood test for detecting HCC using GNB4 and Riplet methylation.

Methods and results

This study mainly investigated the analytical performance of the dual-target HCC blood test (DT-HBT), including cut-off value, limit of detection (LOD), precision, analytical specificity, and coincidence rate. In addition, the detection performance for HCC was validated in 1030 clinical plasma samples (214 HCC and 816 non-HCC). Plasma samples from 25 HCC patients after hepatectomy were collected to assess the

SUBMITTER: Yang Q 

PROVIDER: S-EPMC11425738 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature