Meta-analysis of small for gestational age births and disinfection byproduct exposures.

ABSTRACT:

Background

Some epidemiological studies show associations between disinfection byproducts (DBPs) and adverse developmental outcomes.

Objectives

We undertook a meta-analysis of epidemiological studies on maternal exposure to trihalomethanes (THMs) and haloacetic acids (HAAs) and risk of small for gestational age (SGA) birth.

Methods

We identified forty-five publications including two reports and five theses via a 2020 literature search. Nineteen study populations from 16 publications met the inclusion criteria and were systematically evaluated. Effect measures were pooled using random effects meta-analytic methods along with cumulative, sub-group and meta-regression analyses to examine between-study heterogeneity and variation in risk across different DBP measures.

SUBMITTER: Summerhayes RJ 

PROVIDER: S-EPMC11425775 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature