Biocompatible Native Hyaluronan Nanofibers Fabricated via Aqueous PEO-Assisted Electrospinning and Heat-Quench Process.

ABSTRACT: Hyaluronan (HA) is widely used in cosmetic and biomedical applications due to its excellent biocompatibility and potential to promote wound healing. Nanofibrous HA, mimicking the extracellular matrix (ECM), is considered promising for therapeutic and cosmetic applications. However, the electrospinning process of HA often necessitates cytotoxic solvents and chemical modifications, compromising its biocompatibility and advantageous properties. In this study, poly(ethylene oxide) (PEO) was added to an aqueous solution of natural HA to improve its spinnability, enabling HA to be electrospun into fibers. The HA was rendered water-insoluble by treatment with an acidic solution, and the amorphized PEO, achieved by heat-quenching, was removed through water washing. This method distinguishes it fro

SUBMITTER: Raje K 

PROVIDER: S-EPMC11425832 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature