Distinct Thalamo-Subcortical Circuits Underlie Painful Behavior and Depression-Like Behavior Following Nerve Injury.

ABSTRACT: Clinically, chronic pain and depression often coexist in multiple diseases and reciprocally reinforce each other, which greatly escalates the difficulty of treatment. The neural circuit mechanism underlying the chronic pain/depression comorbidity remains unclear. The present study reports that two distinct subregions in the paraventricular thalamus (PVT) play different roles in this pathological process. In the first subregion PVT posterior (PVP), glutamatergic neurons (PVP^Glu) send signals to GABAergic neurons (VLPAG^GABA) in the ventrolateral periaqueductal gray (VLPAG), which mediates painful behavior in comorbidity. Meanwhile, in another subregion PVT anterior (PVA), glutamatergic neurons (PVA^Glu) send signals to the nucleus accumbens D1-positive neurons

SUBMITTER: Deng J 

PROVIDER: S-EPMC11425852 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature