Molecular genotyping reveals multiple carbapenemase genes and unique bla_OXA-51-like (oxaAb) alleles among clinically isolated Acinetobacter baumannii from a Philippine tertiary hospital.

ABSTRACT:

Background

Acinetobacter baumannii continued to be an important Gram-negative pathogen of concern in the clinical context. The resistance of this pathogen to carbapenems due to the production of carbapenemases is considered a global threat. Despite the efforts to track carbapenemase synthesis among A. baumannii in the Philippines, local data on its molecular features are very scarce. This study aims to characterize A. baumannii clinical isolates from a Philippine tertiary hospital through genotyping of the pathogen's carbapenemase genes.

Methods

Antibiotic susceptibility profiling, phenotypic testing of carbapenemase production, and polymerase chain reaction assays to detect the different classes of carbapenemase genes (class A bla_KPC, class B bla_NDM, b

SUBMITTER: Carascal MB 

PROVIDER: S-EPMC11426070 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature