Incidence of de novo malignancy and all-cause mortality among heart transplant recipients.

ABSTRACT:

Background

Heart transplant recipients develop cancer at two-times the rate compared to the general population. However, the incidence and mortality rates and the adjusted association between cancer and mortality remains unclear.

Methods

We estimated the incidence and mortality rates and the adjusted association between developing cancer (any, skin, hematologic, and solid tumor subtypes) and the all-cause mortality rates among adult heart transplant recipients from the Scientific Registry of Transplant Recipients from October 1, 1987, until June 28, 2020.

Results

Among 51,597 adult heart transplant recipients, 13,191 (25.6%) were diagnosed with de novo malignancy throughout the follow-up period. The cumulative incidence cancer at years 1, 5, 10, and 20 was 3%, 16.4%,

SUBMITTER: Barrera FJ 

PROVIDER: S-EPMC11426084 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature