A million-cow genome-wide association study of productive life in U.S. Holstein cows.

ABSTRACT:

Background

Productive life (PL) of a cow is the time the cow remains in the milking herd from first calving to exit from the herd due to culling or death and is an important economic trait in U.S. Holstein cattle. The large samples of Holstein genomic evaluation data that have become available recently provided unprecedented statistical power to identify genetic factors affecting PL in Holstein cows using the approach of genome-wide association study (GWAS).

Methods

The GWAS analysis used 1,103,641 Holstein cows with phenotypic observations on PL and genotypes of 75,282 single nucleotide polymorphism (SNP) markers. The statistical tests and estimation of SNP additive and dominance effects used the approximate generalized least squares method implemented by the EPISNPmpi comp

SUBMITTER: Liang Z 

PROVIDER: S-EPMC11426094 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature