Non-thermal atmospheric pressure plasma induces selective cancer cell apoptosis by modulating redox homeostasis.

ABSTRACT:

Background

Anticancer treatments aim to selectively target cancer cells without harming normal cells. While non-thermal atmospheric pressure plasma (NTAPP) has shown anticancer potential across various studies, the mechanisms behind its selective action on cancer cells remain inadequately understood. This study explores the mechanism of NTAPP-induced selective cell death and assesses its application in cancer therapy.

Methods

We treated HT1080 fibrosarcoma cells with NTAPP and assessed the intracellular levels of mitochondria-derived reactive oxygen species (ROS), mitochondrial function, and cell death mechanisms. We employed N-acetylcysteine to investigate ROS's role in NTAPP-induced cell death. Additionally, single-cell RNA sequencing was used to compare gene expression in

SUBMITTER: Yun JH 

PROVIDER: S-EPMC11426099 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature