Natural hydrogen gas and engineered microalgae prevent acute lung injury in sepsis.

ABSTRACT:

Background

Hydrogen gas and microalgae both exist in the natural environment. We aimed to integrate hydrogen gas and biology nano microalgae together to expand the treatment options in sepsis.

Methods

Phosphoproteomics, metabolomics and proteomics data were obtained from mice undergoing cecum ligation and puncture (CLP) and inhalation of hydrogen gas. All omics analysis procedure were accordance with standards. Multi R packages were used in single cell and spatial transcriptomics analysis to identify primary cells expressing targeted genes, and the genes' co-expression relationships in sepsis related lung landscape. Then, network pharmacology method was used to identify candidate drugs. We used hydrophobic-force-driving self-assembly method to construct dihydroquercetin (DQ)

SUBMITTER: Wang Y 

PROVIDER: S-EPMC11426111 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature