Association between miRNAs in serum at 10-14 gestational weeks and spontaneous preterm delivery.

ABSTRACT:

Introduction

Preterm delivery (PTD) is the leading cause of death in children under 5 years of age. Cervical shortening detected by ultrasound can be used to predict PTD, but prediction is not perfect, and complementary diagnostic markers are needed. Recently, specific plasma microribonucleic acid (miRNAs) detected in early second trimester were shown to be associated with spontaneous PTD in high-risk women with a singleton pregnancy. The aim of this study was to explore to what extent these miRNAs are associated with spontaneous PTD and cervical length in a general population.

Material and methods

This study is a nested case-control study within the CERVIX study. The CERVIX study evaluated the ability of cervical length screening with transvaginal ultrasound to identify wom

SUBMITTER: Wikstrom T 

PROVIDER: S-EPMC11426222 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature