Air bag-embedded MIL-101(Fe) metal-organic frameworks for an amplified tumor microenvironment activation loop through strategic delivery of iron ions and lentinan.

ABSTRACT: Background: Iron-based nanocarriers have demonstrated potential in redirecting tumor associated macrophages (TAMs) polarization towards the M1 phenotype, critical for activating the tumor microenvironment (TME) in triple negative breast cancer (TNBC). However, their real-world effectiveness is curtailed by insufficient Fe^2+/3+ exposure and the absence of suitable synergists in tumors. Methods: We introduce an air bag-embedded iron-based MIL-101 metal-organic frameworks (MOF_MIL-101(Fe)) for igniting the TME in TNBC through bubble-driven tumoral codelivery of Fe^2+/3+ and lentinan. This system, named HM/Ef/LNT-MOF_MIL-101(Fe), features nano-sized MOF_MIL-101(Fe) as the core, embedded NaHCO₃ as a pH-triggered air bag

SUBMITTER: Han T 

PROVIDER: S-EPMC11426244 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature