Antimicrobial activities of Diltiazem Hydrochloride: drug repurposing approach.

ABSTRACT:

Background

The growing concern of antibiotic-resistant microbial strains worldwide has prompted the need for alternative methods to combat microbial resistance. Biofilm formation poses a significant challenge to antibiotic efficiency due to the difficulty of penetrating antibiotics through the sticky microbial aggregates. Drug repurposing is an innovative technique that aims to expand the use of non-antibiotic medications to address this issue. The primary objective of this study was to evaluate the antimicrobial properties of Diltiazem HCl, a 1,5-benzothiazepine Ca₂ ⁺ channel blocker commonly used as an antihypertensive agent, against four pathogenic bacteria and three pathogenic yeasts, as well as its antiviral activity against the Coxsackie B4 virus (CoxB4)

SUBMITTER: Alduaij OK 

PROVIDER: S-EPMC11426324 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature