RNAMotifProfile: a graph-based approach to build RNA structural motif profiles.

ABSTRACT: RNA structural motifs are the recurrent segments in RNA three-dimensional structures that play a crucial role in the functional diversity of RNAs. Understanding the similarities and variations within these recurrent motif groups is essential for gaining insights into RNA structure and function. While recurrent structural motifs are generally assumed to be composed of the same isosteric base interactions, this consistent pattern is not observed across all examples of these motifs. Existing methods for analyzing and comparing RNA structural motifs may overlook variations in base interactions and associated nucleotides. RNAMotifProfile is a novel profile-to-profile alignment algorithm that generates a comprehensive profile from a group of structural motifs, incorporating all base interactions

SUBMITTER: Rahaman MM 

PROVIDER: S-EPMC11426329 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature