Altered brain serotonin 5-HT_1A receptor expression and function in juvenile Fmr1 knockout mice.

ABSTRACT: There are no approved pharmacotherapies for fragile X syndrome (FXS), a rare neurodevelopmental disorder caused by a mutation in the FMR1 promoter region that leads to various symptoms, including intellectual disability and auditory hypersensitivity. The gene that encodes inhibitory serotonin 1A receptors (5-HT_1ARs) is differentially expressed in embryonic brain tissue from individuals with FXS, and 5-HT_1ARs are highly expressed in neural systems that are disordered in FXS, providing a rationale to focus on 5-HT_1ARs as targets to treat symptoms of FXS. We examined agonist-labeled 5-HT_1AR densities in male and female Fmr1 knockout mice and found no differences in whole-brain 5-HT_1AR expression in adult control compared to Fmr1 knockout

SUBMITTER: Saraf TS 

PROVIDER: S-EPMC11426339 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature