Circulating total and intact GDF-15 levels are not altered in response to weight loss induced by liraglutide or lorcaserin treatment in humans with obesity.

ABSTRACT:

Background

Growth differentiation factor 15 (GDF-15) is a stress-response cytokine proposed to be associated with body weight regulation.

Aims

The primary aim was to investigate changes of circulating intact GDF-15 (wildtype, non-carrier of the rs1058587 polymorphism coding for the H2O2D mutation) and total GDF-15 (measured irrespective of the mutation) in response to liraglutide (GLP-1 receptor agonist) and lorcaserin (5-HT2C receptor agonist), two pharmacologic agents that induce food intake and weight reduction. In addition, we perform exploratory correlations of total and intact GDF-15 with clinical, hormonal and metabolo-lipidomic parameters in humans with obesity.

Materials and methods

We utilized two studies: 1) Study 1, a randomized, double-blinded, cross-over

SUBMITTER: Valenzuela-Vallejo L 

PROVIDER: S-EPMC11426964 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature