A tool to predict the risk of lower extremity amputation in patients starting dialysis.

ABSTRACT:

Background

Non-traumatic lower extremity amputation (LEA) is a severe complication during dialysis. To inform decision-making for physicians, we developed a multivariable prediction model for LEA after starting dialysis.

Methods

Data from the Swedish Renal Registry (SNR) between 2010 and 2020 were geographically split into a development and validation cohort. Data from Netherlands Cooperative Study on the Adequacy of Dialysis (NECOSAD) between 1997 and 2009 were used for validation targeted at Dutch patients. Inclusion criteria were no previous LEA and kidney transplant and age ≥40 years at baseline. A Fine-Gray model was developed with LEA within 3 years after starting dialysis as the outcome of interest. Death and kidney transplant were treated as competing events. One coe

SUBMITTER: Akerboom B 

PROVIDER: S-EPMC11427081 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature