Gene Therapy for Cardiovascular Disease: Clinical Perspectives.

ABSTRACT: Cardiovascular disease (CVD) stands as one of the leading causes of death in the United States, with its prevalence steadily on the rise. Traditional therapeutic approaches, such as pharmacological treatment, cardiovascular intervention, and surgery, have inherent limitations. In response to these challenges, cardiac gene therapy has emerged as a promising alternative for treating CVD patients. However, several obstacles persist, including the low efficiency of gene transduction, immune reactions to vectors or transduced cells, and the occurrence of off-target effects. While preclinical research has demonstrated significant success in various CVD model in both small and large animals, the translation of these findings to clinical applications has, for the most part, yielded disappointing r

SUBMITTER: Lee YS 

PROVIDER: S-EPMC11427124 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature